PP405 Hair Tonic 0.05% concentration.
PP405 is a topical small molecule developed designed to treat hair loss by reawakening dormant hair follicle stem cells. It shows promise for androgenetic alopecia (pattern baldness) by metabolically activating follicles rather than targeting hormones showing increased hair density in 8 weeks.
Key Details About PP405:
Mechanism: PP405 works by inhibiting the mitochondrial pyruvate carrier (MPC) in hair follicle stem cells, shifting their metabolism to activate growth.
Trial Results:
Men with higher degrees of hair loss show an increase in hair density after 8 weeks of daily application.
Application: It is a non-hormonal, topical treatment.
Limitations: It may not work in advanced, fully scarred balding areas, as it requires existing (though dormant) follicles to function
GHK-Cu (copper peptide) in hair tonics and serums are used to support hair follicle health, stimulate growth, and reduce inflammation, often used as a non-hormonal alternative or complement to minoxidil. They work by increasing follicle size and improving scalp health, generally applied once or twice daily to the scalp.
Benefits of GHK-Cu in Hair Tonics:
Mechanism: GHK-Cu is a natural peptide that repairs tissue and boosts collagen production. It stimulates growth factors, reduces inflammation (a key cause of hair loss), and improves blood flow to the scalp, which nourishes follicles.
Benefits: It helps increase hair follicle size, promotes thicker, fuller-looking hair, and can reduce shedding.
Application: It is best applied directly to the scalp as a serum or tonic in concentrations of 0.05%
Hair Tonic - PP405 + GHK-Cu
Key Benefits of GHK-Cu in Hair Tonic:
Encourages Growth: It is considered a potent agent for hair growth, acting as a regenerative agent that increases the size of hair follicles.
Reduces Hair Thinning: Improves scalp health and reduces inflammation, leading to less hair thinning and breakage.
Enhances Scalp Health: It enhances blood flow to the scalp, creating an optimal environment for hair to grow.
Safety Profile: Generally considered safe and suitable for many hair types, often used in, for example, the Neurogan GHK-Cu Copper Peptide Hair & Scalp Serum to promote a healthy scalp
